Mefloquine: What It Is and How It Works

If you’re planning a trip to a malaria‑risk area, you’ve probably heard of mefloquine. It’s an antimalarial pill that has been used for decades to keep the parasite away from your bloodstream. The drug works by stopping the malaria parasites from growing inside red blood cells, so you stay healthy while you travel.

When and How to Take Mefloquine

You start mefloquine before you leave – usually a week ahead – then keep taking it every week for the whole time you’re in the risky zone. After you return, you need to finish the course for another four weeks. The standard adult dose is 250 mg once a week; kids get a lower amount based on weight.

Take the tablet with food and plenty of water. Swallow it whole – don’t chew or crush it – because that can increase stomach upset. If you miss a dose, take it as soon as you remember unless the next dose is due, then skip the missed one and continue your schedule.

Side Effects You Should Watch For

Mefloquine is generally safe when you follow the instructions, but some people notice side effects. The most common ones are nausea, dizziness, and headaches. These usually go away after a few days as your body gets used to the drug.

A smaller group reports more serious issues like vivid dreams, anxiety, or mood changes. If you feel unusually nervous, have trouble sleeping, or notice any strange thoughts, talk to a doctor right away. Rarely, mefloquine can cause severe allergic reactions – look out for rash, swelling, or breathing problems.

People with a history of epilepsy, depression, or heart rhythm problems should be extra careful. Your doctor may suggest a different antimalarial if you fall into any high‑risk category.

Tips to Stay Safe While Using Mefloquine

Before you start the drug, let your healthcare provider know about all medicines you take – especially antidepressants or anti‑seizure pills. Some drugs interact with mefloquine and can boost side effects.

Keep a travel journal of any symptoms you notice, even if they seem minor. This helps your doctor decide whether to keep you on the medication or switch to another option.

If you’re pregnant or nursing, avoid mefloquine unless your doctor says it’s absolutely necessary. For breastfeeding moms, the drug can pass into milk and affect the baby.

Alternatives to Mefloquine

When mefloquine isn’t a good fit, doctors often recommend atovaquone‑proguanil (Malarone), doxycycline, or chloroquine (where resistance is low). Each alternative has its own dosing schedule and side‑effect profile, so discuss the pros and cons with your clinician.

In short, mefloquine can be a reliable shield against malaria if you use it correctly. Pay attention to how your body reacts, follow the weekly dosing plan, and keep an open line with your doctor. With those steps in place, you’ll lower the risk of getting sick while exploring the world.